Single-Channel Recording of Ligand-Gated Ion Channels
نویسندگان
چکیده
منابع مشابه
Allosteric coupling in ligand-gated ion channels
What does " allosteric " mean? In the context of receptors, the word allosteric is now widely used. It is, perhaps, not helpful for clarity of thought that different authors often use it to mean somewhat different things (Colquhoun, 1998). At one extreme, the term " allosteric antagonist " can often be translated as " we have got an antagonist and we are not sure what it does, but it appears no...
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The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits. A database has been developed to handle the growing wealth of cloned subunits. This database contains nucle...
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Ligand-Gated Ion Channels (LGIC) are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits and the last two decades revealed an unexpected wealth of genes coding for these subunits. The Ligand-Gated Ion Channel database (LGICdb) has been developed to handle this increasing amount of data. The database ...
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Ivermectin acts as a positive allosteric regulator of several ligand-gated channels including the glutamate-gated chloride channel (GluCl), gamma aminobutyric acid type-A receptor, glycine receptor, neuronal alpha7-nicotinic receptor and purinergic P2X4 receptor. In most of the ivermectin-sensitive channels, the effects of ivermectin include the potentiation of agonist-induced currents at low c...
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Ligand-gated ion channels mediate fast synaptic transmission in the central and peripheral nervous system and the neuromuscular junction. Their common principle of function is the conversion of a chemical signal--neurotransmitter binding--into an electrical signal, i.e., an ion influx into the postsynaptic cell. The transient nature of this signal requires experimental setups that provide adequ...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Protocols
سال: 2016
ISSN: 1940-3402,1559-6095
DOI: 10.1101/pdb.top087239